期刊
BIOMOLECULAR NMR ASSIGNMENTS
卷 15, 期 2, 页码 397-402出版社
SPRINGER
DOI: 10.1007/s12104-021-10036-5
关键词
Tuberculosis; Polyketide cyclase; NMR; Chemical shift assignment
资金
- National Key Research and Development Project of China [2016YFA0500600]
The study reported the NMR resonance assignments for MtPC, predicting its secondary structure. This represents a first step towards researching the structure and function of MtPC.
Polyketide cyclase from Mycobacterium tuberculosis (MtPC) is related to the formation of sterol derivatives, which may play a role in immune escape in the initial stage of macrophage infection by Mycobacterium tuberculosis. However, the structure and specific functions of MtPC are still unknown. Here we report the backbone and side-chain NMR resonance assignments for the MtPC. Most resonances were assigned and the secondary structure was predicted according to the assigned backbone resonances by TALOS-N and PECAN. These NMR assignments represent a first step towards researching the structure and function of MtPC.
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