Pushbutton-activated microfluidic cartridge as a user-friendly sample preparation tool for diagnostics

Microfluidic technologies have several advantages in sample preparation for diagnostics but suffer from the need for an external operation system that hampers user-friendliness. To overcome this limitation in microfluidic technologies, a number of user-friendly methods utilizing capillary force, degassed poly(dimethylsiloxane), pushbutton-driven pressure, a syringe, or a pipette have been reported. Among these methods, the pushbutton-driven, pressure-based method has a great potential to be widely used as a user-friendly sample preparation tool for point-of-care testing or portable diagnostics. In this Perspective, we focus on the pushbutton-activated microfluidic technologies toward a user-friendly sample preparation tool. The working principle and recent advances in pushbutton-activated microfluidic technologies are briefly reviewed, and future perspectives for wide application are discussed in terms of integration with the signal analysis system, user-dependent variation, and universal and facile use.

Automated summary

This Perspective discusses the advantages and limitations of microfluidic technologies in sample preparation, focusing on the potential and future development of pushbutton-activated microfluidic technologies as user-friendly sample preparation tools. It briefly reviews the working principle and recent advances in pushbutton-activated microfluidic technologies, and discusses future prospects for wide application in terms of integration with the signal analysis system, user-dependent variation, and universal and facile use.