4.7 Review

The current understanding on the impact of KRAS on colorectal cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Oncology

Prognostic value of KRAS mutation in patients undergoing pulmonary metastasectomy for colorectal cancer: A systematic review and meta-analysis

Junfeng Huang et al.

Summary: This study found that KRAS mutation is associated with worse overall survival and recurrence free survival in colorectal cancer patients undergoing pulmonary metastasectomy, along with 18 other factors showing significant effects. This supports the use of a comprehensive model including clinicopathological and biological factors for optimal patient selection and prognosis in surgical treatment.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Article Pathology

Histological growth patterns and molecular analysis of resected colorectal lung metastases

Emanuela Pilozzi et al.

Summary: This study investigated histological patterns of metastases and mutations in MAPkinase pathway genes in colorectal lung metastasis (CLM) patients, showing that C pattern metastases had significantly worse disease-free survival (DFS). KRAS mutations were observed in 39% of patients, with codon 13 mutations associated with synchronous metastasis and poor prognosis. No mutations were found in exon 2 of NRAS gene, while 1.4% harbored a mutation in BRAF, indicating a potential prognostic role of KRAS mutations and histological patterns in CLM.

PATHOLOGY RESEARCH AND PRACTICE (2021)

Review Oncology

Gene mutation and surgical technique: Suggestion or more?

Yoshikuni Kawaguchi et al.

SURGICAL ONCOLOGY-OXFORD (2020)

Article Biochemistry & Molecular Biology

Therapeutic targeting of RAS: New hope for drugging the undruggable

Imran Khan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Pharmacology & Pharmacy

Novel Polymethoxylated Chalcones as Potential Compounds Against KRAS-Mutant Colorectal Cancers

Alaa Mahmoud et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Review Biochemistry & Molecular Biology

Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers

Tyler E. Mattox et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Impact of RAS mutations on the immune infiltrate of colorectal liver metastases: A preliminary study

Michela Anna Polidoro et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

Review Cell Biology

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

Ufuk Degirmenci et al.

Article Pharmacology & Pharmacy

Selumetinib: First Approval

Anthony Markham et al.

Review Gastroenterology & Hepatology

BRAF and KRAS mutations in metastatic colorectal cancer: future perspectives for personalized therapy

Zi-Nan Li et al.

GASTROENTEROLOGY REPORT (2020)

Review Oncology

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Win Topatana et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Medicine, General & Internal

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

David S. Hong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials

Nagendra S. Yarla et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Development of synthetic lethality in cancer: molecular and cellular classification

Shijie Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Biochemistry & Molecular Biology

KRasG12C inhibitors in clinical trials: a short historical perspective

Lisa Goebel et al.

RSC MEDICINAL CHEMISTRY (2020)

Review Oncology

RAC1 as a Therapeutic Target in Malignant Melanoma

Alexa C. Cannon et al.

TRENDS IN CANCER (2020)

Article Medicine, Research & Experimental

Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications

Jun Ye et al.

BIOMEDICAL REPORTS (2020)

Article Medical Laboratory Technology

A Highly Verified Assay for KRAS Mutation Detection in Tissue and Plasma of Lung, Colorectal, and Pancreatic Cancer

Jing Li et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2019)

Article Biochemistry & Molecular Biology

K-RasG12D Has a Potential Allosteric Small Molecule Binding Site

Huizhong Feng et al.

BIOCHEMISTRY (2019)

Review Oncology

Targeting mTOR for cancer therapy

Hui Hua et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Medicine, Research & Experimental

Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study

Kamila Wojas-Krawczyk et al.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

Drugging an undruggable pocket on KRAS

Dirk Kessler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biotechnology & Applied Microbiology

The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis

Yaqin Bie et al.

DISEASE MARKERS (2019)

Review Biochemistry & Molecular Biology

Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors

Hui Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Pharmacology & Pharmacy

Pharmacological targeting of RAS: Recent success with direct inhibitors

John P. O'Bryan

PHARMACOLOGICAL RESEARCH (2019)

Article Multidisciplinary Sciences

KRAS and NRAS pyrosequencing screening in Tunisian colorectal cancer patients in 2015

Raja Jouini et al.

HELIYON (2019)

Article Microbiology

Detection of respiratory bacterial pathogens causing atypical pneumonia by multiplex Lightmix® RT-PCR

Karoline Wagne et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2018)

Article Oncology

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Manuela Porru et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Biochemistry & Molecular Biology

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation

Kathleen A. Boyle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Oncology

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca et al.

ANNALS OF TRANSLATIONAL MEDICINE (2018)

Article Oncology

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer

Julien Taieb et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer

Julien Taieb et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Infectious Diseases

Mucosa-associated microbiota signature in colorectal cancer

R. Gao et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

Review Oncology

Targeting metabolic reprogramming in KRAS-driven cancers

Kenji Kawada et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2017)

Review Medicine, Research & Experimental

Next-generation sequencing: recent applications to the analysis of colorectal cancer

Filippo Del Vecchio et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Review Biochemistry & Molecular Biology

Current Development Status of MEK Inhibitors

Ying Cheng et al.

MOLECULES (2017)

Article Biochemistry & Molecular Biology

MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1

Hongxing Shen et al.

CELL DEATH AND DIFFERENTIATION (2017)

Article Biochemistry & Molecular Biology

Multivalent Small-Molecule Pan-RAS Inhibitors

Matthew E. Welsch et al.

Editorial Material Oncology

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down

G. Aaron Hobbs et al.

CANCER CELL (2016)

Article Surgery

Predictors of Safety and Efficacy of 2-Stage Hepatectomy for Bilateral Colorectal Liver Metastases

Guillaume Passot et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2016)

Article Medicine, Research & Experimental

Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells

Takashi Shingu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

Article Biochemical Research Methods

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

Josiah E. Hutton et al.

MOLECULAR & CELLULAR PROTEOMICS (2016)

Article Genetics & Heredity

Novel Approach for Clinical Validation of the cobas KRAS Mutation Test in Advanced Colorectal Cancer

Abha Sharma et al.

MOLECULAR DIAGNOSIS & THERAPY (2016)

Review Biotechnology & Applied Microbiology

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Jonathan M. L. Ostrem et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Medicine, General & Internal

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Eric Tran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Biochemistry & Molecular Biology

Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

Sally Temraz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Biochemistry & Molecular Biology

The consensus molecular subtypes of colorectal cancer

Justin Guinney et al.

NATURE MEDICINE (2015)

Article Oncology

Association between KRAS mutation and lung metastasis in advanced colorectal cancer

A. A. L. Pereira et al.

BRITISH JOURNAL OF CANCER (2015)

Review Biochemistry & Molecular Biology

Structures of Ras superfamily effector complexes: What have we learnt in two decades?

Helen R. Mott et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Pharmacology & Pharmacy

Beyond KRAS status and response to anti-EGFR therapy in metastatic colorectal cancer

Geraldine Perkins et al.

PHARMACOGENOMICS (2014)

Review Biochemistry & Molecular Biology

KRAS: feeding pancreatic cancer proliferation

Kirsten L. Bryant et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Editorial Material Pediatrics

What is next generation sequencing?

Sam Behjati et al.

ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION (2013)

Article Medicine, General & Internal

Panitumumab-FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer

Jean-Yves Douillard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

KRAS gene mutation in colorectal cancer

Ivan Roa et al.

REVISTA MEDICA DE CHILE (2013)

Article Oncology

The KRAS StripAssay for detection of KRAS mutation in Egyptian patients with colorectal cancer (CRC): A pilot study

Yasser Abd El Kader et al.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2013)

Review Oncology

A Comprehensive Survey of Ras Mutations in Cancer

Ian A. Prior et al.

CANCER RESEARCH (2012)

Review Oncology

Treatment Decisions After Diagnosis of Metastatic Colorectal Cancer

Thomas H. Cartwright

CLINICAL COLORECTAL CANCER (2012)

Article Multidisciplinary Sciences

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability

Tuoping Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

David Matallanas et al.

MOLECULAR CELL (2011)

Review Gastroenterology & Hepatology

The intestinal microbiota and chronic disorders of the gut

Andrew W. DuPont et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2011)

Review Oncology

RAS oncogenes: weaving a tumorigenic web

Yuliya Pylayeva-Gupta et al.

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

Matthias Drosten et al.

EMBO JOURNAL (2010)

Review Biotechnology & Applied Microbiology

Clinical Relevance of KRAS in Human Cancers

Sylwia Jancik et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

Article Oncology

Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer

Federica Di Nicolantonio et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Review Pharmacology & Pharmacy

High-resolution DNA melting analysis for simple and efficient molecular diagnostics

Gudrun H. Reed et al.

PHARMACOGENOMICS (2007)

Article Biochemistry & Molecular Biology

Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS)

Keith I. E. McLuckie et al.

NUCLEIC ACIDS RESEARCH (2006)