The interaction between miRNAs/lncRNAs and Notch pathway in human disorders

Notch pathway is a signaling cascade with important impacts on cell proliferation, differentiation, developmental processes and tissue homeostasis. This pathway also regulates stem cell properties, thus being involved in both normal developmental processes and metastatic capacity of cancer cells. Lots of lncRNAs and miRNAs have been recognized that control Notch pathway at some levels or their expression is regulated by this pathway. FOXD2-AS1, MEG3, ANRIL, linc-OIP5, lincRNA-p21, CBR3-AS1, HOTAIR, PVT1 and GAS5 are among lncRNAs that interact with Notch signaling. miR-19, miR-21, miR-33a, miR-8/200, miR-34a, miR-146a, miR-37, miR-100, miR-107 and several other miRNAs have functional interplay with this signaling cascade. In the present review article, we have illuminated the interplay between lncRNAs/miRNAs and Notch pathway in two distinct contexts i.e. cancers and non-neoplastic conditions.

Automated summary

The Notch pathway plays a crucial role in cell proliferation, differentiation, development, and tissue homeostasis, and is also involved in regulating stem cell properties and cancer cell metastasis. Various long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with the Notch signaling cascade, playing important functional roles in both cancer and non-neoplastic conditions.