期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 138, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111350
关键词
Curcumae Rhizoma; Anti-cancer; beta-elemene; Curcumol; Furanodiene; Terpenoids
资金
- National Natural Science Foundation of China [81403103, 82073994]
- International Cooperation Project of Science and Technology Department of Sichuan Province [2018HH0122]
- Chengdu Science and Technology Bureau International Science and Technology Cooperation Project [2017GH0200054HZ]
- Outstanding Young Scientific and Technological Talents Project of Science and Technology Department of Sichuan Province [2020JDJQ0049]
- Xinglin Scholars Research Enhancement Program [XSGG2019005, QNXZ2018026]
- Science and Technology Transformation Project of Chengdu University of Traditional Chinese Medicine [CGPY1605]
- Key Research and Development Projects of Sichuan Science and Technology Plan [2020YFN0152]
Cancer, a fatal disease with no known cure, has prompted research into traditional Chinese medicine for potential anticancer agents. Compounds like beta-elemene from Curcumae Rhizoma have shown promise as potential anticancer drugs, with ongoing clinical trials showing positive results. This review highlights the efficacy of Curcumae Rhizoma and its terpenoids in cancer therapy, offering potential for the development of new anticancer drugs.
Cancer is a fatal disease with high mortality and low survival rate worldwide. At present, there is still no known cure for most cancers. Traditional Chinese medicine (TCM) represents a noteworthy reservoir for anticancer agents in drug discovery and development. Curcumae Rhizoma (called Ezhu in Chinese) is widely prescribed in TCM for anticancer therapy owing to its broad-spectrum antineoplastic activities. Especially, the terpenoids isolated from the essential oil of Curcumae Rhizoma form an integral part of cancer research and are well established as a potential anticancer agent. For example, beta-elemene has been developed into a new drug for the treatment of solid tumors in China, and is currently undergoing clinical trials in the United States. The review aims to systematically summarize the recent advances on the anticancer effects and related molecular mechanisms of Curcumae Rhizoma, and its terpenoids (beta-elemene, Furanodiene, Furanodienone, Germacrone, Curcumol, Curdione). In addition, we evaluated and compared the anticancer efficacy and clinical use of the terpenoids with combination therapies and traditional therapies. Therefore, this review provides sufficient evidence for the anticancer therapeutic potential of Curcumae Rhizoma and its terpenoids, and will contribute to the development of potential anticancer drugs.
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