期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 139, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111598
关键词
Fracture healing; Pyrroloquinoline quinone; Oxidative stress
资金
- General Project of Medical Science and Technology Development in Nanjing [YKK15240]
The study showed that PQQ can prevent and protect against delayed bone fracture healing induced by OVX by inhibiting oxidative stress, promoting osteoblastic bone formation, and inhibiting osteoclastic bone resorption. This provides insight into the mechanism of PQQ supplementation in promoting fracture healing and supports its potential clinical application in bone fracture treatment.
It is reported that oxidative stress plays a detrimental role in the process of bone fracture healing. And pyrroloquinoline quinone (PQQ) is used as antioxidant. However, there is no report about whether PQQ supplementation can promote fracture healing by eliminating oxidative stress. To investigate the protective effect of PQQ on fracture healing, open mid-diaphyseal femur fractures model were created in sham, ovariectomized (OVX) mice and PQQ-treated OVX mice. Our results confirmed that PQQ played a preventive and protective role in OVX-induced delay of bone fracture healing by inhibiting oxidative stress, subsequently promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption. The findings of this study not only revealed the mechanism of PQQ supplementation in promoting fracture healing, but also provide experimental and theoretical basis for the clinical application of PQQ in the treatment of bone fracture.
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