4.7 Article

Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 139, 期 -, 页码 -

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111669

关键词

Potentilla anserina L polysaccharide; Hypobaric hypoxia; High altitude pulmonary edema; Oxidative stress; Inflammation

资金

  1. National Natural Science Foundation of China [51873175]
  2. Natural Science Foundation of Gansu Province [17JR5RA332]
  3. Top Project of Medical Technology for youth of PLA [16QNP055]
  4. Funding for Basic Scientific Research of China's Central Universities [31920200010]
  5. Special Foundation projects for guiding technological innovation and development of Gansu Province [2019ZX-05]
  6. University research and innovation team project of Gansu Province [2018C-04]

向作者/读者索取更多资源

This study demonstrated the therapeutic potential of Potentilla anserina L polysaccharide (PAP) for high-altitude pulmonary edema (HAPE), mainly by reducing lung edema and protecting lung tissue through suppression of oxidative stress and inflammatory reactions.
High-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties which could be beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric hypoxia test and anti-acute hypoxia test. Then we established a model of HAPE and measured the lung water content, pathological changes and MDA, NO, SOD, GSH concentrations in lung tissues. We also evaluated the protein and mRNA levels of pro-inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha, VEGF, NF-kappa B and HIF-1 alpha) by ELISA kits, RT-PCR and Western blotting. As expected, PAP could dramatically reduce the lung water content, alleviate lung tissue injury, and inhibit MDA and NO production, it also promote SOD activity and GSH expression. In addition, it has been found that PAP blocked the NF-kappa B and HIF-1 alpha signaling pathway activation, inhibited the generation of downstream pro-inflammatory cytokines. Therefore, PAP provides great potential in HAPE treatment mainly through suppression of oxidative stress and inflammatory suppression.

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