期刊
EXPERIMENTAL EYE RESEARCH
卷 142, 期 -, 页码 76-82出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2015.03.021
关键词
Fibrosis; Glaucoma; Surgery; Mechanotransduction; TGF-beta; Extracellular matrix
资金
- Interdiziplinares Zentrum fur Klinische Forschung (IZKF) Wurzburg (IZKF) [A-41/1]
- Deutsche Ophthalmologische Gesellschaft (DOG)
Despite advances in surgical technique and postoperative care, fibrosis remains the major impediment to a marked reduction of intraocular pressure without the need of additional medication (complete success) following filtering glaucoma surgery. Several aspects specific to filtering surgery may contribute to enhanced fibrosis. Changes in conjunctival tissue structure and composition due to preceding treatments as well as alterations in interstitial fluid flow and content due to aqueous humor efflux may act as important drivers of fibrosis. In light of these pathophysiological considerations, current and possible future strategies to control fibrosis following filtering glaucoma surgery are discussed. (C) 2015 Elsevier Ltd. All rights reserved.
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