期刊
BIOMEDICAL MATERIALS
卷 16, 期 5, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1748-605X/ac14cc
关键词
Fe(II); Fe(III); mineralization assay; bioactive glass; in vitro biological interactions; bone
资金
- CONICET, Argentina (DAAD, Germany)
- CONICET, Argentina (Ministerio de Educacion, Argentina)
- ANPCyT, Argentina [PICT 2015-1266]
- CITIUS-University of Seville (Seville, Spain) [VI-PPIT-JGLS-684]
The study shows that magnetic Fe-HA coated scaffolds based on iron-loaded hydroxyapatite nanoparticles displayed good biocompatibility in vitro, promoting hydroxyapatite formation and providing support for human MG-63 cells and mouse ST-2 cell line.
Magnetic 45S5 bioactive glass (BG) based scaffolds covered with iron-loaded hydroxyapatite (Fe-HA-BG) nanoparticles were obtained and its cytotoxicity investigated. Fe-HA nanoparticles were synthesized by a wet chemical method involving the simultaneous addition of Fe2+/Fe3+ ions. BG based scaffolds were prepared by the foam replica procedure and covered with Fe-HA by dip-coating. Fe-HA-BG magnetic saturation values of 0.049 emu g(-1) and a very low remanent magnetization of 0.01 emu g(-1) were observed. The mineralization assay in simulated body fluid following Kokubo's protocol indicated that Fe-HA-BG scaffolds exhibited improved hydroxyapatite formation in comparison to uncoated scaffolds at shorter immersion times. The biocompatibility of the material in vitro was assessed using human osteoblast-like MG-63 cell cultures and mouse bone marrow-derived stroma cell line ST-2. Overall, the results herein discussed suggest that magnetic Fe-HA coatings seem to enhance the biological performance of 45S5 BG based scaffolds. Thus, this magnetic Fe-HA coated scaffold is an interesting system for bone tissue engineering applications and warrant further investigation.
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