A multiscale optimisation method for bone growth scaffolds based on triply periodic minimal surfaces

Tissue engineered bone scaffolds are potential alternatives to bone allografts and autografts. Porous scaffolds based on triply periodic minimal surfaces (TPMS) are good candidates for tissue growth because they offer high surface-to-volume ratio, have tailorable stiffness, and can be easily fabricated by additive manufacturing. However, the range of TPMS scaffold types is extensive, and it is not yet clear which type provides the fastest cell or tissue growth while being sufficiently stiff to act as a bone graft. Nor is there currently an established methodology for TPMS bone scaffold design which can be quickly adopted by medical designers or biologists designing implants. In this study, we examine six TPMS scaffold types for use as tissue growth scaffolds and propose a general methodology to optimise their geometry. At the macro-scale, the optimisation routine ensures a scaffold stiffness within suitable limits for bone, while at the micro-scale it maximises the cell growth rate. The optimisation procedure also ensures the scaffold pores are of sufficient diameter to allow oxygen and nutrient delivery via capillaries. Of the examined TPMS structures, the Lidinoid and Split P cell types provide the greatest cell growth rates and are therefore the best candidates for bone scaffolds.

Automated summary

Tissue engineered bone scaffolds based on triply periodic minimal surfaces (TPMS) offer high surface-to-volume ratio and tailorable stiffness, but the optimal scaffold type for rapid cell or tissue growth remains unclear. This study examines six TPMS scaffold types and proposes a methodology to optimize their geometry for use as bone grafts, with the Lidinoid and Split P cell types identified as the best candidates for promoting cell growth.