期刊
BIOMATERIALS
卷 273, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120807
关键词
Ultrathin Cu chalcogenide; Layered double hydroxide; Topotactic transformation; Synergistic therapy
资金
- National Natural Science Foundation of China [NSFC: 21971007, 21671013, 21521005]
- Fundamental Research Funds for the Central Universities [XK1802-6, XK1803-05]
A copper-loaded CoCuFe-selenide nanocomposite with synergistic photothermal and gas therapy effects was prepared, releasing NO gas in the tumor microenvironment for targeted treatment. In vitro and in vivo experiments demonstrated its efficacy in tumor elimination.
Previous preclinical and clinical studies have shown that using only a single therapy makes it difficult to completely eradicate tumors and restrain cancer metastasis. To overcome this challenge, multi-modal synergistic treatments have attracted considerable attention. Herein, an ultrathin Cu-loaded CoCuFe-selenide (CCFS) was prepared by a facile topotactic transformation from CoCuFe layered double hydroxide (LDH) nanosheets (NSs), followed by surface modification with polyvinyl pyrrolidone (PVP) and L-arginine (L-Arg). The resultant CCFSPVP-L-Arg (CPA) system shows excellent synergetic photothermal and gas therapy (PTT/GT). The CCFS NSs have strong LSPR absorbance characteristic, with enhanced light absorption in the near-infrared (NIR) region. This endows the CPA nanocomposite with an outstanding photothermal conversion efficiency of 72.0% (pH 7.4) and 81.0% (pH 5.4), among the highest reported for 2D chalcogenide nanomaterials. In addition, NO release from CPA is triggered by decomposition of L-Arg in the H2O2-rich and acidic tumor microenvironment, permitting localized NO gas therapy in the tumor site. In vitro experiments revealed 91.8% apoptosis of HepG2 cells, and in vivo studies showed complete tumor elimination upon treatment with the CPA nanocomposite under NIR irradiation. To the best of our knowledge, this is the first report of combined defect-induced high-efficiency PTT with H2O2 and pH targeted GT.
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