期刊
BIOMATERIALS
卷 273, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120827
关键词
Albumin; Ginsenoside; COVID-19; NETosis; Cytokine storm
资金
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [2018R1A2A3075013, 2021R1C1C1009320, 2018M3A7B4071204, 2017R1A5A2015385, 2020R1A4A3078645, 2020R1A2C1004131, 2021R1C1C2006896, 2020R1A4A4079817]
- Korea Health Technology RAMP
- D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health AMP
- Welfare, Republic of Korea [HI15C0001]
- National Research Foundation of Korea [2021R1C1C1009320, 2020R1A4A4079817, 2021R1C1C2006896, 2018M3A7B4071204, 2020R1A4A3078645] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study proposes the use of drug-loaded albumin nanoparticles as a therapeutic agent for severe SARS-CoV-2 patients. The engineered blood vessel model confirmed the effectiveness of the drugs in suppressing blood clot formation and vascular inflammation. Animal model experiments demonstrated that the drugs improved survival rates by reducing tissue damage and cytokine storm.
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on a global scale urges prompt and effective countermeasures. Recently, a study has reported that coronavirus disease-19 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with a decrease in albumin level, an increase in NETosis, blood coagulation, and cytokine level. Here, we present drug-loaded albumin nanoparticles as a therapeutic agent to resolve the clinical outcomes observed in severe SARS-CoV-2 patients. PEGylated nanoparticle albumin-bound (PNAB) was used to promote prolonged bioactivity of steroidal ginsenoside saponins, PNAB-Rg6 and PNAB-Rgx365. Our data indicate that the application of PNAB-steroidal ginsenoside can effectively reduce histone H4 and NETosis-related factors in the plasma, and alleviate SREBP2-mediated systemic inflammation in the PBMCs of SARS-CoV-2 ICU patients. The engineered blood vessel model confirmed that these drugs are effective in suppressing blood clot formation and vascular inflammation. Moreover, the animal model experiment showed that these drugs are effective in promoting the survival rate by alleviating tissue damage and cytokine storm. Altogether, our findings suggest that these PNAB-steroidal ginsenoside drugs have potential applications in the treatment of symptoms associated with severe SARS-CoV-2 patients, such as coagulation and cytokine storm.
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