期刊
BIOMARKERS IN MEDICINE
卷 15, 期 15, 页码 1309-1317出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2021-0144
关键词
biomarker; HOXA9; methylation; ovarian cancer; ovarian malignancy; ovarian tumors
资金
- Department of Oncology, Lillebaelt Hospital, University Hospital of Southern Denmark
- Region of Southern Denmark [19/15008]
- NEYE Foundation, Denmark
This study found a high detection rate of meth-HOXA9 in ovarian cancer and borderline tumors, while a lower rate in benign ovarian tumors. Using ROC analysis, meth-HOXA9 showed a high diagnostic accuracy, suggesting its potential as a general diagnostic marker for ovarian malignancy.
Aim: In ovarian cancer, methylated HOXA9 (meth-HOXA9) has been proposed as a relevant biomarker, however, its role in the carcinogenic development remains unknown. This study aimed at evaluating meth-HOXA9 as a diagnostic biomarker in ovarian cancer. Materials & methods: The meth-HOXA9 status was examined in 138 tissue specimens encompassing normal ovaries, benign- and borderline tumors, and ovarian cancer using droplet digital PCR. Results: Meth-HOXA9 was detected in 93% (82/88) and 88% (14/16) of ovarian cancer and borderline tumors, respectively. In patients with benign ovarian tumors meth-HOXA9 was detected in 17% (3/18). Using receiver operating characteristic (ROC) analysis meth-HOXA9 had a diagnostic accuracy of 98%. Conclusion: Meth-HOXA9 is highly cancer specific and could serve as a general diagnostic marker of ovarian malignancy.
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