LncRNA NEAT1 correlates with Th1 and Th17 and could serve as an assistant biomarker in sepsis

Aim: Investigating correlation of lncRNA NEAT1 with Th1 and Th17 in sepsis, and their associations with inflammation, disease severity and prognosis. Materials & methods: A total of 127 sepsis patients and 50 health subjects were included. LncRNA NEAT1, Th1, Th17 and Th1/Th17-secreted cytokines were detected. Results: LncRNA NEAT1 positively correlated with Th1 and Th17 cell proportions in sepsis patients. LncRNA NEAT1 positively correlated with Th1 and Th17-secreted cytokine levels in sepsis patients. LncRNA NEAT1 and Th17 cell proportion positively correlated with CRP level, acute physiology and chronic health evaluation II score and sequential organ failure assessment score. High lncRNA NEAT1 expression, Th1 and Th17 cell proportions correlated with elevated accumulating mortality. Conclusion: LncRNA NEAT1 positively correlated with Th1 and Th17, and may serve as an assistant biomarker in sepsis patients.

Automated summary

The study found that lncRNA NEAT1 is positively correlated with Th1 and Th17 cell proportions in sepsis patients, and is associated with disease severity and prognosis.