期刊
BIOMARKERS IN MEDICINE
卷 15, 期 11, 页码 911-928出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2020-0776
关键词
biomarkers; cancer; cardiovascular disease; diabetes; sialic acid
资金
- MRC
- Ludger Ltd.
Elevated sialic acid concentration in plasma and serum is positively correlated with the presence of cardiovascular disease, diabetes, and malignant tumors. While not a specific marker, sialic acid shows promise as a marker for monitoring disease progression and treatment effectiveness.
Cardiovascular disease (CVD), diabetes and cancer pose increasing global healthcare burdens. New biomarkers could enable earlier diagnosis of these diseases, leading to more effective treatment and lower associated healthcare burden. Elevated sialic acid concentration in plasma and serum has been positively correlated with the presence of CVDs, diabetes and the development of malignant tumors. This article reviews the use of total sialic acid (TSA), bound sialic acid (BSA) and free sialic acid (FSA) as potential biomarkers for these diseases and makes a comparison with existing markers. Elevated sialic acid has been shown to be indicative of the pathogenesis of CVD, diabetes and malignant tumors. While not a specific marker for one disease there is promise in utilizing sialic acid as a marker for monitoring disease progression and effectiveness of treatment programs.
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