期刊
BIOMACROMOLECULES
卷 22, 期 10, 页码 4337-4346出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c00881
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资金
- National Research Foundation (NRF) of Korea grant [2018R1C1B5085386, 2021R1C1C1008148]
- Nano.Material Technology Development Program [2009-0082580]
- National Research Foundation of Korea (NRF) [NRF-2020R1A2C2101111]
- National Research Foundation of Korea [2018R1C1B5085386, 2021R1C1C1008148] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A simple method for controlled assembly of silk sericin fibers based on their secondary structure via wet-spinning was reported, producing stable linear fibers. Plasticization of silk sericin using glycerol immobilized with glutaraldehyde resulted in stable fibers with self-adhesion. Incorporation of cyclo-phenylalanine nanowires into the silk sericin dope demonstrated potential in artificial silk production.
Silk contains an adhesive glycoprotein, silk sericin, in which silk fibroins can be enfolded and chemically stabilized. Silk sericin is gaining importance as the material for the creation of functional bioscaffolds. However, the assembly of silk sericin is generally limited to the blend of polymers or proteins due to its inherent poor mechanical strength. Here, we report a simple macroscopic controlled assembly of silk sericin fibers based on their secondary structure via wet-spinning. In addition, plasticization of silk sericin using glycerol immobilized with glutaraldehyde was found to induce dimensional stability, affording stable linear fibers with self-adhesion. Furthermore, cyclo-phenylalanine nanowires were incorporated into the silk sericin dope for a practical demonstration of their potential in artificial silk production with superstructure formation. The physicochemical characteristics of the spun fibers have also been elucidated using Fourier-transform infrared spectroscopy, electron microscopy, tensile test, differential scanning calorimetry, and 2D X-ray diffraction.
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