期刊
BIOMACROMOLECULES
卷 22, 期 7, 页码 3119-3127出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c00553
关键词
-
资金
- AMED [JP19H0276, JP20H05230, JP20H04825]
- [JP21ak0101132h0002]
This study evaluates the correlation between the monomer structures of glycopolymers and their interactions with ConA, finding that the acrylate-type glycopolymers exhibit stronger interaction due to the higher molecular mobility of mannose units resulting from the rotational freedom of ester bonds in their side chains.
Molecular mobility is important for interactions of biofunctional polymers with target molecules. Monomer structures for synthetic biofunctional polymers are usually selected based on their compatibility with polymerization systems, whereas the influence of monomer structures on the interaction with target molecules is hardly considered. In this report, we evaluate the correlation between the monomer structures of glycopolymers and their interactions with concanavalin A (ConA) with respect to the molecular mobility. Two types of glycopolymers bearing mannose are synthesized with acrylamide or acrylate monomers. Despite the similar structures, except for amide or ester bonds in the side chains, the acrylate-type glycopolymers exhibit stronger interaction with ConA both in the isothermal titration calorimetry measurement and in a hemagglutination inhibition assay. Characterization of the acrylate-type glycopolymers suggests that the higher binding constant arises from the higher molecular mobility of mannose units, which results from the rotational freedom of ester bonds in their side chains.
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