期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 200, 期 5, 页码 2223-2232出版社
SPRINGERNATURE
DOI: 10.1007/s12011-021-02819-7
关键词
Gold nanoparticles; Biosynthesis; Eryngium thyrsoideum Bioss; Biochemical parameters; Diabetic rats
资金
- University of Mohaghegh Ardabili and Shahid Beheshti University
Gold nanoparticles were successfully synthesized using Eryngium thyrsoideum Boiss plant extract, showing potential as a management option for diabetes-related complications due to their anti-inflammatory and hypoglycemic effects on type 2 diabetic rats.
In this work, we synthesized and reported gold nanoparticles (Au NPs) with Eryngium thyrsoideum Boiss plant extract for first time. The plant extract has important effect as reducing and stabilizing agent for preparation of Au nanoparticles. The synthesized gold nanoparticles were characterized with FT-IR, UV-vis, XRD, SEM, and TEM analyses. All analyses confirmed successful synthesis of gold nanoparticles with high purity. The antidiabetic activity of synthesized Au NPs was investigated on type 2 diabetic rats by studying their influences on serum biochemical parameters and inflammatory markers. Obtained results revealed that hepatic enzymes, TNF-alpha, and interleukin-6 of diabetic rats receiving gold nanoparticles decreased in compare with healthy control rats. As inflammatory markers are main reasons for hyperglycemic-induced insulin resistance in diabetes, Au NPs have a possible option for management of the diabetes-related complication via their potent anti-inflammatory and hypoglycemic effects.
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