期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 200, 期 5, 页码 2365-2379出版社
SPRINGERNATURE
DOI: 10.1007/s12011-021-02835-7
关键词
Mercury (Hg); Selenium (Se); Thioredoxin reductase; Glutathione peroxidase; Selenogene transcription; Seafood; Fish; Dicentrarchus labrax
资金
- Spanish MINECO [RTC-2014-2837-2, CTM2012-40203-C02-01]
- Euskampus Fundazioa-Campus of International Excellence [307615SAA2]
- Basque Government Elkartek [KK-2016/00057]
Different levels of mercury were found to have different effects on the growth and redox gene activities in the liver of Dicentrarchus labrax, while the molar ratio of selenium and mercury also played a role in these effects.
Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively affected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the transcription of txn1, gpx1, and txnrd2. Feeding 6.7 mg Hg/kg for 53 days downregulated the genes of the thioredoxin system (txn1, txnrd3, and txnrd2) but upregulated gpx1, confirming the previously proposed complementarity among the antioxidant systems. Substitution of 20% of the feed by thawed white fish (hake) slightly counteracted the negative effects of Hg. The effects were not statistically significant and were dependent, in a non-linear manner, on the Se/Hg molar ratio of the feed but not on its Hg concentration. These results stress the need to consider the Se/Hg molar ratio of the feed/food when evaluating the toxicity of Hg.
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