期刊
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
卷 15, 期 6, 页码 1938-1949出版社
WILEY
DOI: 10.1002/bbb.2279
关键词
Sophorolipid; biological tailoring; biosurfactant; structural diversity; advanced industry
资金
- National Key R & D Program of China [2019YFA0905500, 2018YFA0902200]
- National Natural Science Foundation of China [22008115, 21978129, 31961133017]
- Jiangsu Province Natural Science Foundation for Youths [SBK2020044721]
- Jiangsu Agriculture Science and Technology Innovation Fund [CX(19)3104]
- China Postdoctoral Science Foundation [2020M671467]
- Project of the State Key Laboratory of Materials-Oriented Chemical Engineering [ZK201801]
Sophorolipid (SL) is a glycolipid surfactant with excellent surface activity and physiological properties, but its mixed structure and expensive separation costs have limited its application in advanced industries. Researchers are now focusing on developing tailored strategies to produce targeted SLs with specific physicochemical properties for use in various industries such as agriculture, cleaning, and medicine.
A sophorolipid (SL) is a kind of glycolipid surfactant that has been much studied due to its excellent surface activity and physiological properties. However, the mixed structure of SLs and expensive separation costs have limited their application in advanced industries. Developing a tailored strategy to produce targeted SLs, with specific physicochemical properties, for direct application in various industries like agriculture, cleaning, and medicine, has become one of the main objectives of SL biological production. In this review, different characteristics of various SLs with various structures are classified in detail. The classification corresponds to their specific applications in different industries. Microorganisms for the production of specific SLs are also summarized, with emphasis on the metabolism pathways and regulation mechanisms. Strategies applied for SL biological tailoring, including selection of fermenting substrates, fermentation process optimization, metabolic engineering and downstream separation, are comprehensively reviewed. (c) 2021 Society of Chemical Industry and John Wiley & Sons, Ltd
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