期刊
BIOFOULING
卷 37, 期 6, 页码 626-655出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2021.1948538
关键词
C; albicans; biofilm; hyphae; natural products; virulence factor; synthetic compounds
资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2019R1A2C1087156, 2021R1A6A1A03039211]
The filamentous morphology of Candida albicans plays a significant role in its pathogenesis, and strategies to inhibit filamentation and reduce virulence are critical in combating infections.
Candida albicans undergoes a morphological yeast-to-hyphal transition during infection, which plays a significant role in its pathogenesis. The filamentous morphology of the hyphal form has been identified as a virulence factor as it facilitates surface adherence, intertwining with biofilm, invasion, and damage to host tissues and organs. Hence, inhibition of filamentation in addition to biofilm formation is considered a viable strategy against C. albicans infections. Furthermore, a good understanding of the signaling pathways involved in response to environmental cues driving hyphal growth is also critical to an understanding of C. albicans pathogenicity and to develop novel therapies. In this review, first the clinical significance and transcriptional control of C. albicans hyphal morphogenesis are addressed. Then, various strategies employed to suppress filamentation, prevent biofilm formation, and reduce virulence are discussed. These strategies include the inhibition of C. albicans filament formation using natural or synthetic compounds, and their combination with other agents or nanoformulations.
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