期刊
BIOCHIP JOURNAL
卷 15, 期 3, 页码 287-295出版社
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-021-00030-3
关键词
COVID-19; Gold microelectrode; Cyclic voltammetry; Square wave voltammetry; Electrochemical biosensor; Raman spectroscopy; Nasal swab
资金
- King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia [5-20-01-031-0009]
- KACST
A highly efficient COVID-19 biosensor was developed, capable of monitoring S protein at lower concentration levels, with high sensitivity and efficiency in detecting COVID-19 in positive human samples.
As continues increasing the COVID-19 infections, there is an urgent need for developing fast, simple, selective, and accurate COVID-19 biosensors. A highly uniform gold (Au) microcuboid pattern was used as a microelectrode that allowed monitoring a small analyte. The electrochemical biosensor was used to monitor the COVID-19 S protein within a concentration range from 100 to 5 pmol L-1; it showed a lower detection limit of 276 fmol L-1. Finally, the developed COVID-19 sensor was used to detect a positive sample from a human patient obtained through a nasal swab; the results were confirmed using the PCR technique. The results showed that the SWV technique showed high sensitivity towards detecting COVID-19 and good efficiency for detecting COVID-19 in a positive human sample.
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