期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1868, 期 9, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2021.119064
关键词
Autophagy; Atg8 proteins; Rab GTPases; Membrane dynamics
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [403222702, 259130777, 423813989, 390939984]
- European Research Council (ERC) under the European Union [769065]
- European Union [765912]
- European Research Council (ERC) [769065] Funding Source: European Research Council (ERC)
Autophagy is a degradative pathway involving controlled lipid and membrane rearrangements to form autophagosomes for turnover within the lytic compartment. Atg8 proteins play a key role in autophagosome biogenesis and interact with various Rab GTPase regulators, potentially linking autophagy progression with Rab GTPase activity. This review focuses on membrane dynamics during autophagosome biogenesis, highlighting the role of Atg8 proteins and selected Rab GTPases.
Autophagy is a degradative pathway during which autophagosomes are formed that enwrap cytosolic material destined for turnover within the lytic compartment. Autophagosome biogenesis requires controlled lipid and membrane rearrangements to allow the formation of an autophagosomal seed and its subsequent elongation into a fully closed and fusion-competent double membrane vesicle. Different membrane remodeling events are required, which are orchestrated by the distinct autophagy machinery. An important player among these autophagy proteins is the small lipid-modifier Atg8. Atg8 proteins facilitate various aspects of autophagosome formation and serve as a binding platform for autophagy factors. Also Rab GTPases have been implicated in autophagosome biogenesis. As Atg8 proteins interact with several Rab GTPase regulators, they provide a possible link between autophagy progression and Rab GTPase activity. Here, we review central aspects in membrane dynamics during autophagosome biogenesis with a focus on Atg8 proteins and selected Rab GTPases.
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