The role of GSK3 in metabolic pathway perturbations in cancer

Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Glycogen synthase kinase 3 (GSK3) lies at the convergence of several signaling axes, including the PI3K/AKT/mTOR, AMPK, and Wnt pathways, which influence cancer initiation, progression and therapeutic responses. Accordingly, GSK3 modulates metabolic processes, including protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy. In this review, we highlight current knowledge of the role of GSK3 in metabolic perturbations in cancer.

Automated summary

Malignant transformation and tumor progression are closely related to perturbations in metabolic programs, with GSK3 playing a crucial role in regulating metabolic processes in cancer, affecting protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy.