期刊
BIOCHEMISTRY AND CELL BIOLOGY
卷 100, 期 1, 页码 1-8出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/bcb-2021-0284
关键词
SLPI; inflammation; nucleus; promoter; transcription; NF-KB; cytokine; TNFa
资金
- Natural Sciences and Engineering Research Council of Canada
SLPI is a small but powerful member of the serine protease inhibitor family with both anti-protease and anti-inflammatory functions. It can inhibit the production of pro-inflammatory cytokines, prevent neutrophil infiltration, and regulate the activity of the transcription factor NF-KB.
Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine protease inhibitor family, which includes proteins such as elafin and a1-antitrypsin. These proteins all have similar structures and antiprotease abilities, but SLPI has been found to have an additional role as an anti-inflammatory factor. It can inhibit the production of pro-inflammatory cytokines in cells stimulated with lipopolysaccharide, prevent neutrophil infiltration in murine models of lung and liver injury, and regulate the activity of the transcription factor NF-KB. In this review, we will revisit SLPI's unique biochemistry, and then explore how its anti-inflammatory functions can be linked to more recent findings showing that SLPI can localize to the nuclei of cells, bind DNA, and act as a regulator of gene expression.
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