Chemical constituents from Lycium barbarum (Solanaceae) and their chemophenetic significance

Phytochemical investigation of the fruit of Lycium barbarum L. has yielded nine alkaloids including one new compound, lycibarbarspermidine T together with eight known compounds. The structures were unambiguously determined by spectroscopic analyses and chemical methods. The chemophenetic significance of all these compounds was summarized. Among the known compounds, compounds 6 and 9 are reported from L. barbarum for the first time, whereas compounds 2-5 have previously been only found in this plant. The anti-inflammatory effects of all compounds were evaluated by measuring the NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS). The results showed that compounds 1-3 and compounds 5-9 could inhibit the NO release of RAW 264.7 cells stimulated by LPS at 30 mu M.

Automated summary

Phytochemical investigation of Lycium barbarum L. fruit has identified nine alkaloids, including a new compound and eight known ones. The compounds show potential anti-inflammatory effects, with some compounds reported for the first time from the fruit of Lycium barbarum L.