Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity

The gamma delta T cell immune cell lineage has remained relatively enigmatic and under-charac-terised since their identification. Conversely, the insights we have, highlight their central importance in diverse immunological roles and homeostasis. Thus, gamma delta T cells are consid-ered as potentially a new translational tool in the design of new therapeutics for cancer and infectious disease. Here we review our current understanding of gamma delta T cell biology viewed through a structural lens centred on the how the gamma delta T cell receptor mediates ligand recognition. We discuss the limited knowledge of antigens, the structural basis of such reactivities and discuss the emerging trends of gamma delta T cell reactivity and implications for gamma delta T cell biology.

Automated summary

γδT cells, a relatively enigmatic immune cell lineage, are considered as a potential new translational tool in the design of therapeutics for cancer and infectious disease due to their central importance in diverse immunological roles and homeostasis. Our current understanding of γδT cell biology focuses on how the γδT cell receptor mediates ligand recognition, highlighting limited knowledge of antigens, the structural basis of reactivities, and emerging trends in γδT cell reactivity.