期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 559, 期 -, 页码 106-112出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.04.090
关键词
Intervertebral disc degeneration; Morin; Pyroptosis; TXNIP
资金
- National Natural Science Foundation of China [81871790, 81572167]
- Shanghai Hospital Development Center Foundation [SHDC12016110]
The study revealed that TXNIP promotes pyroptosis in NP cells via the NLRP3/Caspase-1/IL-10 signaling pathway, while Morin shows significant inhibitory effects on the TXNIP/NLRP3/Caspase-1 signaling pathway, potentially serving as an effective therapeutic agent for IDD.
Intervertebral disc degeneration (IDD) is a major cause of lower back pain (LBP), a condition that causes a heavy economic burden globally. The production of cytokines, including interleukin (IL)-10 and tumor necrosis factor (TNF) a, is increased in the degenerating intervertebral disc. Thioredoxin-interacting protein (TXNIP) participates in NLRP3 inflammasome-dependent pyroptosis in liver. Therefore, we hypothesized that TXNIP maypromote pyroptosis via NLRP3/Caspase-1/IL-10 signaling pathway in nucleus pulposus (NP) cell. This study examined the effects of TXNIP on IDD, explored the underlying mechanisms of action and find Morin which is the inhibitor of TXNIP can attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration. Our findings indicate that TXNIP promote pyroptosis via NLRP3/Caspase-1/IL-10 signaling pathway in NP cell. Morin considerably inhibited the TXNIP/NLRP3/Caspase-1 signaling pathway in vitro. In vivo. Our data show that TXNIP can aggravates intervertebral disc degeneration and morin may be a useful therapeutic agent for IDD. (c) 2021 Elsevier Inc. All rights reserved.
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