4.6 Article

Hypomethylation-driven overexpression of HJURP promotes progression of hepatocellular carcinoma and is associated with poor prognosis

期刊

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.05.102

关键词

Hepatocellular carcinoma; HJURP; Tumor progression; Prognosis; Centromere maintenance

资金

  1. Guangxi Natural Science Foundation Program [2017GXNSFBA198041, 2017GXNSFAA198103]
  2. Guangxi Medical and Health Appropriate Technology Development and Application Project [S2020100]
  3. key planning development research program of Guangxi
  4. Science and Technology Program of Tianjin [18PTSYJC00120]

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HJURP is identified as a crucial oncogene promoting HCC progression, with its high expression significantly associated with patient survival. HJURP enhances tumorigenesis through reducing cell arrest and increasing invasiveness in HCC.
Our previous studies have initially identified HJURP, which encodes a Holliday junction recognizing protein, as a hepatocellular carcinoma (HCC) susceptibility gene. In this report, we showed that the HJURP is highly expressed in HCC tissues compared to adjacent normal tissues. Overexpression of HJURP in HCC tissues is mainly due to the hypomethylation of HJURP promoter region. Clinically, high expression of HJURP is significantly associated with poor overall survival and disease-free survival of patients with HCC, as well as in multiple other types of cancer. Gain-and loss-of functional studies demonstrated that HJURP promotes HCC cell proliferation, clone formation, migration and invasion. Additionally, HJURP enhances HCC tumorigenesis via reducing G0/G1 arrest and apoptosis. Mechanistically, by gene set enrichment analysis (GSEA) analysis, HJURP was identified as a modulator involved in CENPA-mediated centromere maintenance. Our results provide evidence of HJURP as an important oncogene that promotes HCC progression, and the HJURP pathway may be a potential target for the treatment of HCC. (c) 2021 Elsevier Inc. All rights reserved.

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