4.6 Article

Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells

期刊

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.07.080

关键词

TSC; mTORC1; LARS1; Amino acids; Cell proliferation

资金

  1. Research Institute of Medical Science, Daegu Catholic University

向作者/读者索取更多资源

In TSC-null cells, leucine is essential for cell proliferation through the activation of LARS1-mTORC1 pathway, and LARS1 inhibitors may be considered as novel tools for reversing tumor growth and proliferation in TSC-null tumor cells.
Uncontrolled cell proliferation associated with cancer depends on the functional abrogation of at least one of tumor suppressor. In response to nutrient cue, tuberous sclerosis complex (TSC) works as a tumor suppressor which inhibits cell growth via negative regulation of the mammalian target of rapamycin complex (mTORC1). However, the regulation mechanism of nutrient-dependent cell proliferation in TSC-null cells remains unclear. Here, we demonstrate that leucine is required for cell proliferation through the activation of leucyl-tRNA synthetase (LARS1)-mTORC1 pathway in TSC-null cells. Cell proliferation and survival were attenuated by LARS1 knock-down or inhibitors in TSC-null cells. In addition, either rapa-mycin or LARS1 inhibitors significantly decreased colony formation ability while their combined treat-ment drastically attenuated it. Taken together, we suggest that LARS1 inhibitors might considered as novel tools for the regression of tumor growth and proliferation in TSC-null tumor cells which regrow upon discontinuation of the mTORC1 inhibition. (c) 2021 Published by Elsevier Inc.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据