期刊
EXPERIMENTAL CELL RESEARCH
卷 340, 期 2, 页码 193-197出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2015.10.028
关键词
Lipid bodies; Inflammation; Eicosanoids; Immune responses; Cell activation; Electron microscopy
资金
- National Institutes of Health (NIH) [USA - R37AI020241, R01AI022571]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil) [477475/2013-2, 469995/2014-9, 311083/2014-5]
- Brazilian Ministry of Health [469995/2014-9]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, Brazil) [CBB APQ 02239/14]
Studies on lipid droplets (LDs) in leukocytes have attracted attention due to their association with human diseases. In these cells, LDs are rapidly formed in response to inflammatory stimuli or allergic/inflammatory diseases including infections with parasites and bacteria. Leukocyte LDs are linked to the regulation of immune responses by compartmentalization of several proteins and lipids involved in the control and biosynthesis of inflammatory mediators (eicosanoids). In this mini review, we summarize current knowledge on the composition, structure and function of leukocyte LDs, organelles now considered as structural markers of inflammation. (C) 2015 Elsevier Inc. All rights reserved.
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