期刊
BEHAVIOURAL PROCESSES
卷 187, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.beproc.2021.104395
关键词
ADHD; Memory; SHR; Restraint stress; Risk behaviour
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq -430746/2016-4]
- Fundacao de Amparo `a Pesquisa do Estado do Rio de Janeiro [FAPERJ E-26/203.284/2016]
The study found that a single episode of stress during adolescence can increase risk behavior and impair short-term memory in adult rats with ADHD, but does not alter locomotion. This suggests that stress during adolescence, even acute, can lead to long-term behavioral consequences in an animal model of ADHD.
Adolescence is a period of increased sensitivity to stress and vulnerability to the manifestation of psychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the relationship between stress during adolescence and ADHD is still unclear. Knowing that stress can have long-term consequences, the aim of this study was to evaluate the impact of a single episode of restraint stress during adolescence on locomotion, risk behaviour and short-term memory in adult spontaneously hypertensive rats (SHR), a validated animal model of ADHD. A single episode of stress during adolescence increased risk behaviour and impaired short-term recognition memory, but did not alter locomotion in adult SHR. These findings show that stress during adolescence, even acute, may lead to long-term behavioural consequences in an animal model of ADHD.
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