期刊
BEHAVIOURAL BRAIN RESEARCH
卷 411, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2021.113388
关键词
Itch; Brain mechanism; Anterior cingulate cortex; Prelimbic cortex; Rats
资金
- National Natural Science Foundation of China [31700913]
- Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0391, cstc2019jcyj-msxmX0269, cstc2019jcyj-msxmX0252]
- Chongqing Medical Research Foundation of Science of Health [2019MSXM015]
This study demonstrated the involvement of prelimbic cortex in itch modulation and revealed the differential roles of caudal anterior cingulate cortex and prelimbic cortex in regulating histaminergic and non-histaminergic itch.
Itch is an unpleasant sensation that evokes a desire to scratch. Itch processing in the peripheral and spinal cord has been studied extensively, but the mechanism of itch in the central nervous system is still unclear. Anterior cingulate cortex (ACC) and prelimbic cortex (Prl), two subregions of the prefrontal cortex closely related to emotion and motivation, have been reported to be activated during itching in a series of functional imaging studies. However, the exact role of Prl and the differences between ACC and Prl in itch modulation remains unknown. To directly test the differential roles of ACC and Prl in itch processing, we chemogeneticlly inhibited the caudal ACC and Prl, respectively. We found that inhibition of caudal ACC reduced histaminergic but not nonhistaminergic itch-induced scratching behaviors. In contrast, inhibition of Prl reduced both histaminergic and non-histaminergic itch-induced scratching behaviors. Our study provided direct evidence of Prl involvement in itch modulation and revealed the differential roles of caudal ACC and Prl in regulating histaminergic and nonhistaminergic itch.
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