期刊
BEHAVIOURAL BRAIN RESEARCH
卷 412, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2021.113445
关键词
Depression; Sucrose preference; Anterior cingulate cortex; Lateral entorhinal cortex; Medial lateral entorhinal cortex
资金
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A181180123902470]
A decreased H1 receptor activity in the anterior cingulate cortex (aCgCx) may lead to behavior changes related to depression. Blocking of H1 receptors in the aCgCx and lateral entorhinal cortex significantly reduces sucrose preference in rats, indicating a potential therapeutic target in depressive disorders.
A decreased H1 receptor activity is observed in the anterior cingulate cortex (aCgCx) of depressed patients. The role of this abnormality in the development of depression-related processes is unstudied. We examined the influence of a decreased brain H1 receptor activity on rat behavior in the sucrose preference test. The H1 receptor deficit was simulated by injection of an H1 antagonist into the aCgCx; also, two aCgCx projection areas, lateral and medial entorhinal cortices were examined. A blockade of H1-receptors in the aCgCx and lateral entorhinal cortex (LEntCx) significantly reduced sucrose preference. These findings suggest the existence of H1 receptormediated aCgCx-LEntCx circuitry mechanism regulating anhedonic-like behavior in rats. The presented data suggest that H1 receptor-mediated processes might be a therapeutic target in depressive disorders.
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