4.6 Article

Putative anxiolytic-like behavioral effects of acute paracetamol in adult zebrafish

期刊

BEHAVIOURAL BRAIN RESEARCH
卷 409, 期 -, 页码 -

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ELSEVIER
DOI: 10.1016/j.bbr.2021.113293

关键词

Cortisol; Anxiety; Behavior; Stress; Acetaminophen; Zebrafish

资金

  1. Research Support Foundation of the State of Rio Grande do Sul (FAPERGS) research fellowships [19/2551-0001669-7]
  2. Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China)
  3. Ministry of Healthcare of Russian Federation [121040200141-4]
  4. Special Rector's Fellowship for St. Petersburg State University (SPSU) students
  5. SPSU [51130521]

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Research shows that paracetamol has an anxiolytic effect on adult zebrafish and can alleviate stress-induced anxiety. This underscores the importance of zebrafish models for drug screening, including the search for potential anti-stress therapies.
Typically triggered by stress, anxiety disorders are most common and widespread mental illnesses. The zebrafish (Danio rerio) is rapidly becoming an important aquatic model species in stress research and central nervous system (CNS) drug screening. Paracetamol is currently the most prescribed medication for pain and fever, and is among the most used drugs globally. However, its CNS effects, especially on anxiety, in both clinical and animal studies remain poorly understood. Capitalizing on zebrafish as a powerful model system, here we evaluate the effects of paracetamol on anxiety-like behavior in adult fish, and its changes following an acute stress exposure. Overall, we report an anxiolytic-like profile of acute paracetamol treatment, and its alleviation of stress-evoked anxiety, in adult short-fin wild type zebrafish. Collectively, these findings suggest complex neuroactive effects of paracetamol, and reinforce the growing importance of zebrafish models for drug screening, including the search for novel putative anti-stress therapies.

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