期刊
BEHAVIOURAL BRAIN RESEARCH
卷 409, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2021.113313
关键词
Passive avoidance memory; Baclofen; Phaclofen; MK-801; Basolateral amygdala
The research revealed that GABA-B receptors in the BLA area can modify the impairing effect of MK-801 on passive avoidance memory.
MK-801 (dizocilpine) is a potent non-competitive N-methyl-[D]-aspartate (NMDA) receptor antagonist that affects cognitive function, learning, and memory. As we know, NMDA receptors are significantly involved in memory function, as well as GABA (Gamma-Aminobutyric acid) receptors. In this study, we aimed to discover the effect of GABA-B receptors in the basolateral amygdala (BLA) on MK-801-induced memory impairment. We used 160 male Wistar rats. The shuttle box was used to evaluate passive avoidance memory and locomotion apparatus was used to evaluate locomotor activity. MK-801 (0.125, 0.25, and 0.5 mu g/rat), baclofen (GABA-B agonist, 0.0001, 0.001, and 0.01 mu g/rat) and phaclofen (GABA-B antagonist, 0.0001, 0.001, and 0.01 mu g/rat) were injected intra-BLA, after the training. The results showed that MK-801 at the dose of 0.5 mu g/rat, baclofen at the doses of 0.001 and 0.01 mu g/rat, and phaclofen at the doses of 0.001 and 0.01 mu g/rat, impaired passive avoidance memory. Locomotor activity did not alter in all groups. Furthermore, the subthreshold dose of both baclofen (0.0001 mu g/rat) and phaclofen (0.0001 mu g/rat) restored the impairment effect of MK-801 (0.5 mu g/rat) on memory. Also, both baclofen (0.0001 mu g/rat) potentiated the impairment effect of MK-801 (0.125 mu g/rat) and phaclofen (0.0001 mu g/rat) potentiated the impairment effect of MK-801 (0.125 and 0.25 mu g/rat) on passive avoidance memory. In conclusion, our results indicated that BLA GABA-B receptors can alter the effect of NMDA inactivation on passive avoidance memory.
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