期刊
BEHAVIOURAL BRAIN RESEARCH
卷 409, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2021.113306
关键词
Basolateral amygdala; Orbitofrontal cortex; Nucleus accumbens; Incentive motivation; Behavioral flexibility; Decision-making
资金
- National Institute on Drug Abuse (NIDA) grant [R01DA043533]
- McKnight Memory and Cognitive Disorders Award (McKnight Foundation)
- Department of Anatomy and Neurobiology at the University of Maryland, School of Medicine
The review discusses the functional projections between the basolateral amygdala (BLA) and its cortical and striatal targets, highlighting their roles in learning, decision-making, choice behaviors, and substance seeking behaviors. It also focuses on the involvement of these projections in motivation disorders, particularly Substance Use Disorder.
To survive in a complex environment, individuals form associations between environmental stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral amygdala (BLA) uses these learned associations to inform decision-making processes. In this review, we describe functional projections between BLA and its cortical and striatal targets that promote learning and motivational processes central to decision-making. Specifically, we compare and contrast divergent projections from the BLA to the orbitofrontal (OFC) and to the nucleus accumbens (NAc) and examine the roles of these pathways in associative learning, value-guided decision-making, choice behaviors, as well as cue and context-driven drug seeking. Finally, we consider how these projections are involved in disorders of motivation, with a focus on Substance Use Disorder.
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