期刊
BEHAVIORAL NEUROSCIENCE
卷 135, 期 3, 页码 369-379出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/bne0000403
关键词
Pavlovian reward learning; Go/No Go learning; ventral striatum; dopamine D2 receptors
资金
- NIMH NIH HHS [R01 MH068073, R01 MH093672] Funding Source: Medline
The upregulation of D2 receptors in ventral striatal neurons does not affect Pavlovian learning or extinction, nor does it alter No-Go learning. However, there is a delay in the Go component of the task, potentially indicating a learning deficit but may also be due to locomotor hyperactivity.
Ventral striatal dopamine is thought to be important for associative learning. Dopamine exerts its role via activation of dopamine D1 and D2 receptors in the ventral striatum. Upregulation of dopamine D2R in ventral striatopallidal neurons impairs incentivemotivation via inhibiting synaptic transmission to the ventral pallidum. Here, we determined whether upregulation of D2Rs and the resulting impairment in ventral striatopallidal pathway function modulates associative learning in an auditory Pavlovian reward learning task as well as Go/No-Go learning in an operant based reward driven Go/No-Go task. We found that upregulation of D2Rs did not affect Pavlovian learning or the extinction of Pavlovian responses, and neither did it alter No-Go learning. We however observed a delay in the Go component of the task which may indicate a deficit in learning though it could also be attributed to the established locomotor hyperactivity of the mice. In combination with previously published findings, our data suggest that D2Rs in ventral striatopallidal neurons play a specific role in regulating motivation by balancing cost/benefit computations but do not necessarily affect associative learning.
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