Persulfidation is the mechanism underlying sulfide-signaling of autophagy

In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved molecular mechanism.

Automated summary

This commentary highlights the recent findings on the H2S regulation of autophagy in mammalian cells and discusses the similarities/divergences with plant cells. The main outcome of the study is the conserved molecular mechanism involving the posttranslational modification of thiol groups on cysteine residues to form persulfides.