期刊
AUTOIMMUNITY REVIEWS
卷 21, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.autrev.2021.102927
关键词
Immunization; COVID-19; Adenoviral associated; Inflammatory bowel disease; Rheumatoid arthritis; Vasculitis; Spondyloarthropathy; Systemic lupus erythematosus
类别
The treatment for COVID-19 often involves immune-modulating drugs, which are also used in immune mediated inflammatory diseases (IMIDs). This systematic review examines the seroconversion after SARS-CoV-2 vaccination in patients with IMIDs and the impact of different drugs on seroconversion rates. The findings suggest that patients with IMIDs have lower seroconversion rates, and certain therapies have no impact on seroconversion rates while others result in poorer responses.
Objectives: The treatment for COVID-19 often utilizes immune-modulating drugs. These drugs are also used in immune mediated inflammatory diseases (IMIDs). We performed a systematic review about seroconversion after SARS-CoV-2 vaccination in patients with IMIDs and impact of various drugs on seroconversion rates. Methods: Electronic databases were searched to identify relevant studies reporting seroconversion rates following SARS-CoV-2 vaccination in IMIDs. We calculated the pooled seroconversion rates after a single or two doses of vaccination, pooled seroconversion rates in patients with specific IMIDs, and rates in patients on various drugs/ drug classes. Results: Twenty-five studies were included in the systematic review. The pooled seroconversion rates after two doses of mRNA vaccination were higher (83.1, 95%CI: 74.9-89.0, I-2 = 90%) as compared to a single dose (69.3, 52.4-82.3, I-2 = 95%). The odds of seroconversion were lower in IMIDs as compared to healthy controls (0.05, 0.02-0.13, I-2 = 21%). The seroconversion rates in patients with inflammatory bowel disease (95.2, 95%CI: 92.6-96.9, I-2 = 0%), spondyloarthropathy (95.6, 95% CI: 83.4-98.9, I-2 = 35%), and systemic lupus erythematosus (90.7, 95%CI: 85.4-94.2, I-2 = 0%) were higher as compared to rheumatoid arthritis (79.5, 95% CI: 65.1-88.9, I-2 = 85%), and vasculitis (70.5, 95% CI: 52.9-83.5, I-2 = 51%). The seroconversion rates following double dose of mRNA were excellent (>90%) in those on anti-tumour necrosis factor (TNF), anti-integrin (vedolizumab), anti-IL 17 (secukinumab), anti-IL6 (Tocilizumab) and anti-IL12/23 (Ustekinumab) therapies but attenuated (<70%) in patients on anti-CD20 (Rituximab) or anti-cytotoxic T lymphocyte associated antigen (CTLA-4) therapies (Abatacept). The seroconversion rates were good (70-90%) with steroids, hydroxychloroquine, JAK inhibitors, mycophenolate mofetil and leflunomide. Combination of anti-TNF with immunomodulators (azathioprine, 6-meracptopurine, methotrexate) resulted in an attenuated vaccine response as compared to anti-TNF monotherapy. Conclusion: Seroconversion rates after SARS-CoV-2 vaccination are lower in patients with IMIDs. Certain therapies (anti-TNF, anti-integrin, anti-IL 17, anti-IL6, anti-12/23) do not impact seroconversion rates while others (anti-CD20, anti-CTLA-4) result in poorer responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据