期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 241, 期 7, 页码 679-688出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370216640385
关键词
Biomarkers; disease severity; phenotype; prediction; prognosis; sickle cell disease; sickle cell anemia; prevention; survival; outcomes; models
资金
- NIH/NHLBI [5U01HL117709]
Sickle cell disease (SCD) is a monogenic, yet highly phenotypically variable disease with multisystem pathology. This manuscript provides an overview of many of the known determinants, modifiers, and correlates of disease severity in SCD. Despite this wealth of data, modeling the variable and multisystem pathology of SCD continues to be difficult. The current status of prediction of specific adverse outcomes and global disease severity in SCD is also reviewed, highlighting recent successes and ongoing challenges.
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