期刊
EXPERIMENTAL BIOLOGY AND MEDICINE
卷 241, 期 9, 页码 955-961出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370216647129
关键词
Immunoisolation; alginate; poly (ethylene glycol); TheraCyte; premature ovarian failure
资金
- Hartwell Foundation [14-PAF00981]
- National Science Foundation Graduate Research Fellowship [DGE 1256260]
This review focuses on the concept of immunoisolation and how this method has evolved over the last few decades. The concept of immunoisolation came out of the need to protect allogeneic transplant tissue from the host immune system and avoid systemic side effects of immunosuppression. The latter remains a significant hurdle in clinical translation of using tissue transplants for restoring endocrine function in diabetes, growth hormone deficiency, and other conditions. Herein, we review the most significant works studying the use of hydrogels, specifically alginate and poly (ethylene glycol), and membranes for immunoisolation and discuss how this approach can be applied in reproductive biology.
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