期刊
EXPERIMENTAL ANIMALS
卷 65, 期 4, 页码 413-418出版社
INT PRESS EDITING CENTRE INC
DOI: 10.1538/expanim.16-0033
关键词
bacterial luciferase; cytolysin A; radiotherapy; Salmonella typhimurium Delta ppGpp; tumor
资金
- Science and Technology Program of Hainan, China [ZDXM20130067, ZDXM2015065]
- Nature Fund [314040]
- Social and Scientific Development Program [SF201421]
The engineered Salmonella typhimurium Delta ppGpp (S.t Delta ppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t Delta ppGpp/pBAD-ClyA. Radiotherapy (21Gy) contributed to S. typhimurium colonization in a colon tumor (CT26) model of BALB/c mice. The combination of bacterial therapy and radiotherapy treatments reduced tumor growth compared with only bacterial therapy.
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