期刊
ARCHIVES OF TOXICOLOGY
卷 95, 期 10, 页码 3425-3432出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-021-03124-x
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资金
- US Air Force [AFOSR FA9550-13-1-0047]
- ExxonMobil Foundation [S18200000000256]
Coronavirus variants are spreading globally, with the United States experiencing a high death toll despite progress in vaccination. The medical community should further investigate the potential of low-dose radiation therapy for COVID-19.
Coronavirus variants are gaining strongholds throughout the globe. Despite early signals that SARS-CoV-2 coronavirus case numbers are easing up in the United States and during the middle of a (not so easy) vaccination roll out, the country has passed a grim landmark of 600,000 deaths. We contend that these numbers would have been much lower if the medical community undertook serious investigations into the potential of low doses of radiation (LDRT) as a mainstream treatment modality for COVID-19 pneumonia. LDRT has been posited to manifest anti-infectious and anti-inflammatory properties at doses of 0.3-1.0 Gy via the activation of the Nrf-2 pathway. Although some researchers are conducting well-designed clinical trials on the potential of LDRT, the deep-rooted, blind, and flawed acceptance of the Linear No-Threshold (LNT) model for ionizing radiation has led to sidelining of this promising therapy and thus unimaginable numbers of deaths in the United States.
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