4.6 Article

Should I stay or should I go? Golgi membrane spatial organization for protein sorting and retention

期刊

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2021.108921

关键词

Transmembrane proteins; Secretory pathway; Glycosylation enzymes; Intra-Golgi traffic; Membrane lipids

资金

  1. Government of Spain [FIS2017-89560-R, RYC-2017-22227, PID2019-106232RB-I00/10.13039/501100011033, CEX2019-000910-S]
  2. Fundacio Privada Cellex
  3. Fundacio Privada Mir-Puig
  4. Generalitat de Catalunya (CERCA, AGAUR)

向作者/读者索取更多资源

The Golgi complex plays crucial roles in maintaining cellular homeostasis, protein processing, and sorting. Understanding the spatial organization of Golgi membranes is essential for its proper functioning, although there remain many unresolved questions in this area.
The Golgi complex is the membrane-bound organelle that lies at the center of the secretory pathway. Its main functions are to maintain cellular lipid homeostasis, to orchestrate protein processing and maturation, and to mediate protein sorting and export. These functions are not independent of one another, and they all require that the membranes of the Golgi complex have a well-defined biochemical composition. Importantly, a finelyregulated spatiotemporal organization of the Golgi membrane components is essential for the correct performance of the organelle. In here, we review our current mechanistic and molecular understanding of how Golgi membranes are spatially organized in the lateral and axial directions to fulfill their functions. In particular, we highlight the current evidence and proposed models of intra-Golgi transport, as well as the known mechanisms for the retention of Golgi residents and for the sorting and export of transmembrane cargo proteins. Despite the controversies, conflicting evidence, clashes between models, and technical limitations, the field has moved forward and we have gained extensive knowledge in this fascinating topic. However, there are still many important questions that remain to be completely answered. We hope that this review will help boost future investigations on these issues.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据