期刊
AQUATIC TOXICOLOGY
卷 238, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aquatox.2021.105926
关键词
Perfluoroctanoic acid; Neurotoxicity; Early-life exposure; Dopaminergic nervous system; Neurobehavior
资金
- National Natural Science Founda-tion of China [41991314]
- Collaborative Innovation Program of Shanghai Municipal Health Commission [2020CXJQ01]
Research using zebrafish as a model has found that early-life exposure to PFOA affects dopaminergic neuron development and leads to neurobehavior changes in zebrafish larvae.
Perfluorooctanoic acid (PFOA) is known as an environmental endocrine disruptor and has developmental neurotoxicity that could be associated with behavior changes in human and animal studies. Previous studies have shown that PFOA might affect the dopaminergic nervous system. However, the mode of action underlying the effects of PFOA remains poorly understood. Our study used zebrafish as an animal model to investigate the effects of early-life PFOA exposure on dopaminergic neuron development and dopamine functions in zebrafish larvae. Zebrafish fertilized eggs were exposed to different concentrations of PFOA (0, 10, 100, 1000 mu g/L). After exposure to PFOA for 7 days, the locomotor activity of zebrafish was decreased; the mRNA levels of nuclear receptor subfamily 4 group a member 2b (nr4a2b), paired box 2 and 5 (pax2, pax5), tyrosine hydroxylase 1/2 (th1/th2) and dopamine transporter (dat) were increased; mRNA and protein level of mesencephalic astrocytederived neurotrophic factor (manf) were decreased. Neural cell proliferation in the preoptic area of hypothalamus was increased. In conclusion, dopaminergic neuron development might be one of the targets of early-life PFOA exposure. The neurobehavior changes induced by PFOA exposure might link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae.
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