期刊
AQUACULTURE RESEARCH
卷 52, 期 12, 页码 6786-6794出版社
WILEY
DOI: 10.1111/are.15495
关键词
Actinobacteria; antivibrio; cytotoxicity; Gelidiella acerosa
类别
资金
- Universitas Gadjah Mada RTA 2020
- LPDP Indonesia [2018-2020]
The study evaluated ten marine Actinobacteria isolated from red seaweed Gelidiella acerosa for their potential antivibrio activity, showing that five isolates exhibited activity against Vibrio species with potential for controlling vibriosis. The presence of nrps genes in all isolates suggests a potential for bioactive peptide production, while the absence of pks I, II and hmgcr genes indicates a different biosynthetic pathway.
Vibriosis causes a problem in aquaculture and human health. The antibiotic resistance and the limited availability of antimicrobial agents are the driving force for searching for new antivibrio compounds from natural products. Herein, we evaluated ten marine Actinobacteria isolated from red seaweed Gelidiella acerosa for antivibriosis, cytotoxicity and secondary metabolites genes in the way to find a new antivibrio agent. Five Actinobacteria isolates exhibited activity against Vibrio alginolyticus and Vibrio parahaemolyticus with MIC ranging from 0.625 to 5 mu g/mu l. All isolates displayed no cytotoxicity against Vero cell line except for isolate DR-2R-115-8. All isolates harbour nrps gene, which might indicate that these isolates have great potential in the production of bioactive peptides while none of the isolates showed the presence of pks I, II and hmgcr genes. Identification of ten isolates of marine Actinobacteria associated with red algae was classified into four genera of Brevibacterium, Nocardiopsis, Allokutzneria and Brachybacterium. Our study revealed that the marine Actinobacteria associated with red algae Gelidiella acerosa were promising sources for controlling vibriosis.
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