期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 44, 期 3, 页码 110-115出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000082
关键词
skeletal muscle; hypertrophy; ribosome; translational capacity; protein synthesis
资金
- National Institutes of Health [AR061939, AR064896]
Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy.
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