High-contrast light focusing through scattering media with multi-pixel encoding

Realizing a high-contrast anti-scattering light focusing by using a spatial light modulation such as a digital micromirror device (DMD) demands a robust optimizer in the process of wavefront shaping. Genetic algorithm (GA) as a common practice can easily be stuck into the inferior local minima. Here, we combined GA with encoding neighboring pixels of DMD to circumvent the inferior local minima. Simulations and experiments have demonstrated that our method could greatly increase the anti-scattering capability when compared with the conventional GA method. This work could be an important step towards deep tissue noninvasive optical imaging, optogenetics, and photodynamic therapy.

Automated summary

By combining genetic algorithm with encoding neighboring pixels of DMD, this study successfully increased the anti-scattering capability, contributing to important advancements in deep tissue noninvasive optical imaging, optogenetics, and photodynamic therapy.