期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 105, 期 14-15, 页码 5785-5794出版社
SPRINGER
DOI: 10.1007/s00253-021-11453-1
关键词
Akkermansia muciniphila; Inflammatory bowel disease; Inflammation; Correlation; treatment
资金
- Nanjing Medical University Fan Daiming Research Funds for HIM
- Graduate Research and Innovation Projects of Jiangsu Province [KYCX19_1171]
- Natural Science Fund for Colleges and Universities in Jiangsu Province, China [20KJD320002]
Akkermansia muciniphila is a promising next-generation probiotic with recognized potential applications in metabolic diseases and tumor immunotherapy. Its safety and therapeutic value in human metabolic diseases have been confirmed in recent clinical trials. Additionally, A. muciniphila shows promise in the treatment of intestinal inflammatory diseases, particularly inflammatory bowel disease (IBD).
Akkermansia muciniphila is a next-generation probiotic with significant application prospects. The role of A. muciniphila in metabolic diseases and tumor immunotherapy has been widely recognized. Recent clinical trials further confirmed its safety and therapeutic value in human metabolic diseases. A. muciniphila also shows potential in the treatment of intestinal inflammatory diseases, especially for inflammatory bowel disease (IBD). The improvement in the efficacy of washed microbiota transplantation (WMT) in treating IBD is closely related to the increase in the abundance of A. muciniphila in patients' gut. However, there is still controversy regarding the pro-inflammatory or anti-inflammatory effect of A. muciniphila on IBD. Currently, several studies targeting the correlation between A. muciniphila and IBD have demonstrated opposite conclusions. Similarly, the interventional studies exploring causality between them also come to conflicting results. This article therefore aims to review the relationship between A. muciniphila and IBD, the effect of intervention of A. muciniphila on IBD, and the possible reasons for the contradictory role of A. muciniphila in the treatment of IBD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据